Hi,
What happens when you install Defender updates? Was there an error message?
Meanwhile, please try to update the definitions using the offline package.
Download mpam-fe.exe from https://go.microsoft.com/fwlink/?LinkID=121721&arch=x64
Run the package. You may not see any output when you run that file.
Once done, run PowerShell (admin) and run the following command:
get-mpcomputerstatus
get-mppreference
Copy the output and post it in your reply.