Site to site domain controllers via VPN in general should not be a problem.
--please don't forget to upvote
and Accept as answer
if the reply is helpful--
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I have a customer who is due for an upgrade on their server, and am thinking if there is a way for them to be less reliant on their premises.
I was just wondering if I setup a Domain Controller in my Server Room and setup a SiteToSite VPN to the customers office and run it all over a VPN whether there would be any major factors which would advise not doing that.
In total there would only be 3 servers hosted over the VPN (DomainController/FileServer/App server)
Site to site domain controllers via VPN in general should not be a problem.
--please don't forget to upvote
and Accept as answer
if the reply is helpful--