
Based on my research and testing, I need to say sorry first.
Currently, using the Alt key to open workbooks in new instances seems a good way for you.
The registry value of DisabelMergeInstance on my test environment does not work on opening workboos, just work for opening Excel app.
The value data "C:\Program Files\Microsoft Office\Root\Office16\EXCEL.EXE" "%1"/x works correctly, but if we need to write to any registry keys besides HKEY_CURRENT_USER, we must have local administrator rights. There is no way around this.
And then there is no other new and effective solution to meet your needs. So I suggest you use Alt key to help you.
Thanks for your understanding.
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