Hi @Richard ,
Welcome to our forum!
Do you mean that registry keys doesn’t work or you can't apply this registry key to 1800 users?
Based on my test on Outlook 365 client, I can disable the option successfully by registry or GPO. How did you apply the registry? Please refer to the below figure and check if there're any differences with yours:
After that, the option is greyed out as shown in the below.
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