Hi @bisondev ,
From the error message, we can see that the application cannot find the certificate file. When configure SSL connectivity in your application, have you ever configured SSL certificate, and whether the certificate is validated or not and the file path is correct? You can check it.
Here are some relates articles, you can refer to them:
Configure SSL connectivity in your application to securely connect to Azure Database for MySQL
Understanding the changes in the Root CA change for Azure Database for MySQL Single Server
Best regards,
Dillion