The additional info indicates optimizations so are you building your solution with the Debug configuration? If not then you need to build using debug settings otherwise the debugger won't be able to show you anything useful.
Also note that this can happen if you are trying to view something that requires code to execute (aka a property) and that code requires that the debugger run other code (hence the thread info in the message).
It seems you are running a debug build. In the screenshot you are not paused in the debugger so, of course, none of the variable windows will work. Can you show a screenshot of what VS looks like when you're paused in the debugger on a breakpoint and when you are watching a variable in scope. Note that if you are watching variables that aren't in scope then it won't work. Alternatively show the Locals or Autos window instead.