Either invoke the Start method or use Timer1_Tick(Nothing, Nothing)
were generally speaking one does not use the parameters.
Private Sub Timer1_Tick(sender As Object, e As EventArgs) Handles Timer1.Tick
Console.WriteLine(Now)
End Sub
Private Sub Button1_Click(sender As Object, e As EventArgs) Handles Button1.Click
Timer1_Tick(Nothing, Nothing)
End Sub