The administration and maintenance of Microsoft Exchange Server to ensure secure, reliable, and efficient email and collaboration services across an organization.
Exchange will use any valid DC it can. It prefers in-site to out of site DCs however.
If you look at even 2080 on the server, you will see how it determines the suitability of the DCs:
https://learn.microsoft.com/en-us/exchange/troubleshoot/administration/msexchangedsaccess-event-id-2080
However, if you want, you can exclude ( or include) the Domain Controllers it uses. I wouldnt say its a normal practice, but you can certainly do this and its supported