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Please consider using multi-subnet AG to setup your scenario. Refer this document once, Simplify Azure SQL Virtual Machines HA and DR configuration by adopting multi subnet approach. AG replicas on different regions are supported by this approach.
The default port for listener will be ok, however the recommendation is to use a different port number – Looking for “WITH IP” in CREATE AVAILABILITY GROUP (Transact-SQL) - SQL Server.
Hope this helps.
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