@Joel Madsen ,
Thank you for reaching out to the Microsoft Q&A platform. Happy to answer your question.
Linux is currently the recommended option for running Python apps in App Service. Python support on Azure App Service for Windows is officially deprecated. As a result, the Publish command in Visual Studio is officially supported only for an IIS target, and remote debugging on Azure App Service is no longer officially supported. However, Publishing to App Service on Windows features still works for the time being, as the Python extensions for App Service on Windows remain available but will not be serviced or updated. For more information, please visit
https://learn.microsoft.com/en-us/azure/app-service/configure-language-python
https://learn.microsoft.com/en-us/visualstudio/python/managing-python-on-azure-app-service?view=vs-2022
https://learn.microsoft.com/en-us/visualstudio/python/publishing-python-web-applications-to-azure-from-visual-studio?view=vs-2022
If the above explanation doesn't address your query, please share more details on the webapp details and screenshots. Please "Accept as Answer" and Upvote if any of the above helped so that, it can help others in the community looking for remediation for similar issues.