Hi @David Mitchell ,
Welcome to our forum!
Do you mean that registry keys doesn’t work or you can't apply this registry key to 1800 users?
Based on my test on Outlook 365 client, I can disable the option successfully by registry or GPO. How did you apply the registry? Please refer to the steps:
If the Registery key issnt availible than you have to make one.
Please follow these steps:
Open Regedit > go to HKCU\software\policies\microsoft\office\16.0\outlook\preferences
If the folder exist than Click right mouse on the folder preferences > New > DWORD 32bit
The value name is ShowAutoSug
Click right mouse on the DWORD > Modify > check if Value data = 0
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