@Rick Thanks for posting in our Q&A.
For this issue, it is not related to windows 365. Windows 365 is a cloud-based service that automatically creates a new type of Windows virtual machine (Cloud PCs) for your end users. this issue seems more related to Microsoft 365 Defender. To get more accurate help, it is suggested to contact Microsoft Defender support. Here is the support link:
https://learn.microsoft.com/en-us/microsoft-365/security/defender-endpoint/contact-support?view=o365-worldwide
Thanks for your understanding and hope everything goes well with you.
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