Microsoft has started removing older patches for things signed with older keys as per
UPDATE: SHA-1 signed content to be retired
Also you really need to move of BizTalk 2010 as not only is it out of support, so it the operating system it runs on, the database it uses, and fairly shortly, the .Net version it runs on.
.NET Framework 4.5.2, 4.6, 4.6.1 will reach End of Support on April 26, 2022