Was any Office update, Windows update, or third-party software installed before this issue occurred?
> works in safe mode, disabled all add-ins
Do you mean that Excel works fine in Safe mode, but you have disabled all add-ins?
If so, please locate to C:\Users\<User Name>\AppData\Roaming\Microsoft\Excel\XLSTART
and C:\Program Files\Microsoft Office\root\Office16\XLStart
, check whether there are some files, such as .xlsm files, then you can temporarily move them elsewhere.
Then I suggest you go to Registry Editor, locate to Computer\HKEY_CURRENT_USER\Software\Microsoft\Office\Excel\Addins
, check whether there is "LoadBehavior" for each registry entry under "Addins", then make sure the data value for "LoadBehavior" is 0.
(Serious problems might occur if you modify the registry incorrectly. Before you modify it, please remember to back up the registry for restoration in case problems occur.)
Besides, I suggest you run following commands in Command Prompt.
dism /online /cleanup-image /scanhealth
dism /Online /cleanup-image /checkhealth
dism /online /cleanup-image /restorehealth
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