Hello,
For the screen flickering problem when opening applications or switching applications on multiple monitors,you can try to check from the following three aspects:
1.Some applications may not be compatible with winodws 11, causing the screen to flicker or be cluttered. At this point, you need to uninstall the application and restart the device to check if the problem is resolved:
https://support.microsoft.com/en-us/windows/troubleshoot-screen-flickering-in-windows-47d5b0a7-89ea-1321-ec47-dc262675fc7b
2.After closing the browser's hardware acceleration configuration, check whether it returns to normal:
Edge Settings>System
Google Chrome Settings>Advanced
Firefox Settings>General>Performance
3.Waiting for the next update version of Windows 11
Best Regards,
Wesley Li