Im guessing you have 3rd party anti-virus or some other installed add-in?
I would disable:
http://clintboessen.blogspot.com/2018/04/third-party-transport-agents-delaying.html
If you have 3rd party anti-virus, ensure its excluding the Exchange Dirs and processes:
Also ensure you are running the latest 2016 CU plus May 2022 SU:
You can check with the healthchecker
https://aka.ms/ExchangeHealthChecker