
Firstly, Microsoft Defender is able to detect and block any form of attack which attempt to exploit this vulnerability, so in case you are using Microsoft Defender make sure it is update and Cloud-delivery protection is on. In case you are using different Anti-Malware product, then check with your Anti-Malware vendor.
It is recommended to backup registry before performing the operation.
You won't need to restart your PC and your normal application won't affected and it only affect MSDT, so if you don't use this tool, then it won't affect you.
Microsoft is investigating and hopefully more details will be released and there would be an update.
Have a look at:
https://msrc-blog.microsoft.com/2022/05/30/guidance-for-cve-2022-30190-microsoft-support-diagnostic-tool-vulnerability/
https://msrc.microsoft.com/update-guide/en-US/vulnerability/CVE-2022-30190