@Skip Hofmann
Thank you for reaching out to us. As @Cristian SPIRIDON mentioned, Azure AD Certificate based authentication enables customers to allow or require users to authenticate with X.509 certificates against their Azure Active Directory (Azure AD) for applications and browser sign-in. where Windows Hello for Business replaces passwords with strong two-factor authentication on devices. This authentication consists of a new type of user credential that is tied to a device and uses a biometric or PIN.
To answer this Can WH4B and CBA used in combination ?
Why not, you can use it, WH4B would have PRT during the sign-ins, provides SSO, you wont get the opportunity to do any other cert ( CBA ). Its something WH4B is used to sign-in and browser want to use "FIDO2" keys.
Implementation wise it is possible but wont be of much helpful, you wont get the opportunity to do that, as SSO takes precedence unless you use private browser.
Let me know if you have any further questions.
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