Hi there,
Yes it is possible to configure NPS server to specific Active Directory Domain. You can use this topic to register a server running Network Policy Server in Windows Server 2016 in the NPS default domain or in another domain.
NPSs must be registered in Active Directory so that they have permission to read the dial-in properties of user accounts during the authorization process. Registering an NPS adds the server to the RAS and IAS Servers group in Active Directory.
Register an NPS in an Active Directory Domain https://learn.microsoft.com/en-us/windows-server/networking/technologies/nps/nps-manage-register
Network Policy Server Best Practices https://learn.microsoft.com/en-us/windows-server/networking/technologies/nps/nps-best-practices
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