The administration and maintenance of Microsoft Exchange Server to ensure secure, reliable, and efficient email and collaboration services across an organization.
So Exchange is just used for management and SMTP routing? It prob safe then to uninstall 2016 , reboot and install 2019 on the same server. You may see errors in the 2019 install if the reg entries and any files remaining after the uninstall remain on the server
However, my preference is to always build a clean server then run the Hybrid Wizard if you can.