Hi @Melissa Hartwell (Hunter New England LHD) ,
Welcome to our forum!
In order to further confirm the issue Is related to the Mouse, please navigate to mail list and use Up/Down key to select the email and press the Delete key or Ctrl+D to check if you delete the email only.
If you just delete the email not all emails in the folder, it's suggested that you could change the Mouse to check if there're any differences.
If all emails in the folder are deleting by Delete key, considering the impact of some add ins, It is suggested that you try to start outlook in safe mode(win+R>type: outlook /safe) to check whether it works normally.
In addition, considering the Outlook program is damaged, it's suggested that you could try to fix the Office application.
Hope the above help!
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