Hi @Shane King ,
According to error information , the main cause may is the SSL certificate is bound incorrectly or is not bound.
Please open Internet Information Services (IIS) Manager in Exchange Server, and have a check that the certificate binding for the default Web site and exchange back end is Microsoft Exchange.
If not , please refer to steps in the following link to reconfiguration your SSL certificate and see if it works.
Server Error in '/owa' Application Exchange Server - ALI TAJRAN
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Besides , when you install Exchange 2019 on a server, three self-signed certificates are created and installed.
Digital certificates and encryption in Exchange Server | Microsoft Learn
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