Hello @Raghu Muthappa ,
Thanks for contacting us!
Per support matrix - https://learn.microsoft.com/en-us/azure/site-recovery/azure-to-azure-support-matrix#region-support "South Africa West" and "South Africa North" falls under supported regions. That being said, you should be able to set DR between these regions.
If you are unable to set up a vault, then it could due to the following reasons:
- You can work within regions for which you have appropriate access.
- If the region in which you want to create a vault doesn't show, make sure your subscription has access to create resources in that region.
- If you can't see a region within a geographic cluster when you enable replication, make sure your subscription has permissions to create VMs in that region.
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