Removing these logs is only safe as long as the CA database file is consistent. In order to remove these logs and reclaim disk space, follow these steps:
- Open the Services MMC and stop the Active Directory Certificate Services service.
- Make a backup copy of ALL the file contents present in the c:windowssystem32certlog folder.
- Delete EDB.CHK and all the files that have an extension of .LOG (*.LOG)
- Restart the Active Directory Certificate Services service.
https://learn.microsoft.com/en-us/archive/blogs/sbs/recovering-disk-space-on-the-c-drive-in-small-business-server-2008#active-directory-certificate-services-transaction-log-files
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