Application Layer Firewall protection for Exchange Server 2003 with ISA Server 2004
Microsoft Internet Security and Acceleration (ISA) Server 2004 provides many features for securely publishing resources to the Internet with the use of application layer filters. The purpose of this document is to detail how to more effectively use the Hypertext Transfer Protocol (HTTP) and Simple Mail Transfer Protocol (SMTP) filtering capabilities to secure a Microsoft Exchange Server 2003 environment connected to the Internet by using ISA Server 2004.
https://www.microsoft.com/technet/prodtechnol/isa/2004/plan/firewall-exchange2003.mspx