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This article was written by Warren Rath, Support Escalation Engineer.
Symptoms
When you try to change the default save location to a SharePoint location in Microsoft Excel 2016 through the Default local file location setting, you receive the following error message:
Cause
For some unknown reasons, some Office 2016 installations can't create a necessary directory.
Workaround
To work around this issue, add the following directory to the systems that are experiencing this issue:
C:\Users\userid\AppData\Roaming\Microsoft\Excel\URL\
Note
You need to change the userid to a real user ID when you add this directory.