Hello,
Thank you for posting in Q&A forum.
To enable Reputation-Based Protection in a domain environment, do the following:
On the Group Policy Management computer, open the Group Policy Management Console, right-click the Group Policy Object you want to configure, and select Edit.
On the Group Policy Editor screen, expand the Computer Configuration folder, and then locate the following item:
Computer Configuration > Policies > Administrative Templates > Windows Components > Windows Defender Antivirus
Enable the item named Configure protection for potentially unwanted applications, and in Options, select Block to block potentially unwanted applications.
For more information, refer to the following links: Tutorial GPO - Enable the Windows Defender reputation based protection (techexpert.tips)
Best Regards,
Yanhong Liu
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