An Office service that supports add-ins to interact with objects in Office client applications.
From the control panel, feature and programs, I repeared the MS Office installation.
Now it works.
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We are facing with the problem that the command launched by SharePoint Launched external handler for 'ms-word:ofe%7Cu%7http://portal/urlToDocument.docx does not launch Word anymore. Doing some check we figured out that the problem appears only one the version 2008 Build 13127, on the 1908 Build 11929 it works. Same for Excel files.
An Office service that supports add-ins to interact with objects in Office client applications.
Answer accepted by question author
From the control panel, feature and programs, I repeared the MS Office installation.
Now it works.