Hi Ketan Sahasrabudhe, thanks for posting in Q&A forum.
There is no need to break the SQL replication during the patching process, but you will need to detach the database from the Secondary Farm before patching.
Here is an article with explanation and tutorial you can refer to: Patching SharePoint with No Downtime using SQL Server AlwaysOn. (Detailed steps can be found in the section “Compatibility Range Confirmed: Perform Read/Write Upgrade”.)
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