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There is some great information on how we design and run our internal Exchange 2007 infrastructure here at Microsoft on the IT Showcase website.
https://www.microsoft.com/technet/itshowcase/exchange.mspx
This includes a podcast on How Microsoft IT Designs Its 64-bit Exchange Server 2007 Infrastructure - https://download.microsoft.com/download/8/9/A/89AA5EDD-DEAE-48DE-9DFD-C2A25A0813C5/bmo110706.mp3