its not supported to have any firewall rules that prevent communication between Exchange and Domain Controllers or to other Exchange Servers
Starting with Exchange Server 2007 and current as of Exchange Server 2013, having network devices blocking ports/protocols between Exchange servers within a single organization or between Exchange servers and domain controllers in an organization is not supported. A network device may sit in the communication path between the servers, but a rule allowing “ANY/ANY” port and protocol communication must be in place allowing free communication between Exchange servers as well as between Exchange servers and domain controllers.