You may disable it using Microsoft Intune, take a look at:
https://learn.microsoft.com/en-us/windows/security/threat-protection/microsoft-defender-antivirus/prevent-changes-to-security-settings-with-tamper-protection
how to enable / disable tamper protection in windows 10 Pro??
how to enable / disable tamper protection in windows 10 Pro??
4 answers
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Reza-Ameri 16,836 Reputation points
2021-02-13T16:30:30.02+00:00 -
Kapil Arya 7,676 Reputation points MVP
2020-05-25T06:20:52.747+00:00 Hello,
You can configure it from Windows Security > Virus & threat protection > Virus & threat protection settings > Manage settings > Turn On/Off Tamper Protection.
To configure with registry, go to HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows Defender\Features.
Take ownership of Features key first.
Create/set TamperProtection DWORD to 0 to disable Tamper Protection or 5 to enable Tamper Protection.
Hope this helps!
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Jenny Feng 706 Reputation points
2020-05-22T02:35:57.557+00:00 Hi,
You could change the tamper protection setting as below:
In the search box on the taskbar, type Windows Security and then select Windows Security in the list of results.
In Windows Security, select Virus & threat protection and then under Virus & threat protection settings, select Manage settings.
Change the Tamper Protection setting to On or Off.
Note: Tamper Protection is turned on by default. If you turn off Tamper Protection, you will see a yellow warning in the Windows Security app under Virus & threat protection.
Also, If the Tamper Protection setting is On, you won't be able to turn off the Microsoft Defender Antivirus service by using the DisableAntiSpyware group policy key.Hope above information can help you.
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Dave Patrick 426.1K Reputation points MVP
2020-05-21T12:08:09.087+00:00 Open Windows Security
Click on the Virus & threat protection
Click on the Manage settings under Virus & threat protection settings
Turn off the Tamper Protection toggle option(please don't forget to Accept as answer if the reply is helpful)
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Regards, Dave Patrick ....
Microsoft Certified Professional
Microsoft MVP [Windows Server] Datacenter ManagementDisclaimer: This posting is provided "AS IS" with no warranties or guarantees, and confers no rights.