Hi @Suy Peang ,
Yes, you can upgrade from CU9 to CU19. Prepare the Active directory with PrepareSchema/PrepareAD.
Upgrade .NET framework to 4.8 which is crucial and Immediately install the Exchange CU19.
https://learn.microsoft.com/en-us/exchange/plan-and-deploy/prepare-ad-and-domains?view=exchserver-2016
https://learn.microsoft.com/en-us/exchange/plan-and-deploy/supportability-matrix?view=exchserver-2019#microsoft-net-framework
You can also check for the best practises,
https://learn.microsoft.com/en-us/exchange/plan-and-deploy/install-cumulative-updates?view=exchserver-2019#best-practices
If the above suggestion helps, please click on "Accept Answer" and upvote it.