Hi,
Yes it is possible to call internationally, however many countries have a history of blocking VoiP applications for use, for example Skype, Teams etc is blocked.
You can license per user for Calling so no worry there. You just need to make sure the numbers you call are supported on the international plan since it doesn't include all numbers, some places won't allow mobile calling etc.
More information here:
What is Phone System?
https://learn.microsoft.com/en-us/MicrosoftTeams/2-envision-make-my-service-decisions-phone-system
Which Calling Plan is right for you?
https://learn.microsoft.com/en-us/microsoftteams/calling-plan-landing-page
Calling Plans for Microsoft 365
https://learn.microsoft.com/en-us/microsoftteams/calling-plans-for-office-365
Here's the calling availability specifically for the UK and US:
(Please don't forget to accept helpful replies as answer)
Best regards,
Leon