- Where is the File Share Witness?
- for the client connectivity, I would continue to use the F5. I assume its spanning the data centers? ( i.e the namespace)
If the connectivity is good between the data centers and Exchange Servers, then yes, the connection will proxy from DC2 to DC1 - assuming you have accounted for how to ensure the clients now go through DC2 and not attempt to use DC1. Round Robin can do this, but its a poor substitute for a real load balancer like an F5.