Hello DarkRookie,
Yes this is possible, by using the LayoutModification.xml and applying during in the Task Sequence for the deployment. This includes removing Search bar or Cortana, removing default apps, adding your own, etc...
Reference:
https://learn.microsoft.com/en-us/windows/configuration/configure-windows-10-taskbar
Additional reference:
https://learn.microsoft.com/en-us/windows/configuration/start-layout-xml-desktop
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