.Net runtime - There was a failure initializing profiling API attach infrastructure - 1022

Dear tocguy,

Thank you for reaching out to the Microsoft Q&A Forum.

The core of the problem is a fundamental incompatibility between Microsoft Office 2016 and your modern Windows 11 ecosystem, especially with cloud-integrated features like Copilot.

You could try these troubleshoots below to solve this issue:

1. Disable the offending scheduled task:
   • Click the Start button and type Task Scheduler, then open it.
   • In the left-hand pane, navigate to Task Scheduler Library > Microsoft > Office.
   • You will likely see several tasks here. The most probable culprit is named something like Office Feature Updates, Office Telemetry Agent, or Office ClickToRun Service Monitor.
   • Right-click on each suspicious task and select Disable.
   • Reboot your computer and check the Event Viewer to see if the .NET errors have stopped.
2. Use Autoruns to find and disable the process:
   • Download Autoruns directly from Microsoft.
   • Extract and run Autoruns64.exe as an administrator.
   • Wait for it to scan everything. In the filter box at the top, type Office.
   • Look through the entries under the Scheduled Tasks and Services tabs. Find any entries related to Office 2016 diagnostics, telemetry, or updates.
   • Uncheck the box next to the entry to disable it.
   • Reboot and check if the error is gone.

For long-term recommendation, your hardware is the absolute latest for 2025. Running Office 2016, which exited mainstream support in 2020, on this platform is not a stable or secure configuration. You will likely continue to encounter strange issues like this.

The only way to guarantee stability and proper functionality is to use a version of Office that is actively supported on Windows 11, such as Microsoft 365 or Office 2021/2024.

Please understand that our initial reply may not always immediately resolve the issue. However, with your help and more detailed information, we can work together to find a solution. Thank you for your cooperation.

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