Dear @Terry Tolson,
Thank you for posting your question in the Microsoft Q&A forum.
The error message "554 5.7.1 Relay Access Denied" usually means that the email server you are trying to send through is blocking your message because it does not recognize you as a legitimate sender.
Generally, the first reason is that your outgoing mail server (SMTP) doesn't allow you to send emails without user authentication. First check your settings in your email application (like Outlook or Thunderbird) to verify that SMTP authentication is enabled.
The other reason is that your email address is marked in spam lists as a source of spam. First check if the email address(es) you are attempting to send the emails to is valid and if there are no spelling mistakes. Secondly, it's possible that your IP address is listed on a real-time blocklist (RBL) that Microsoft Exchange Online Protection uses.
Therefore, here's the Microsoft Official Fixed I recommend you try: Fix NDR error "550 5.7.1" in Exchange Online
If the issue still persists, could you please confirm these questions below to help me narrow down the issue more effectively:
- Can you confirm whether the affected address is a Microsoft 365 business mailbox, a personal Outlook.com/Hotmail account, or a third‑party email account?
- To better understand the scenario, could you confirm whether you’re using the New Outlook or the Classic Outlook client?
- Is the bounce affecting all external senders, or only specific domains or senders?
- Is the recipient mailbox hosted on Microsoft 365 / Exchange Online, or another mail platform?
Note: Please understand that as a forum moderator, my role is to provide general guidance and troubleshooting support. I don’t have access to internal systems or backend tools, and I appreciate your understanding of these limits.
I hope the information shared helps point you in the right direction. Please try the steps above and let me know if they work. If not, we can continue working together to narrow this down.
The first response may not always resolve the issue right away, but with your help and more details, we can work toward a solution.
Thank you for your patience and understanding. I'm looking forward for your reply.
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