Hi @Evgeny Shupik ,
Glad to know that your issue is resolved now! Since our forum has the policy that The question author cannot accept their own answer, I would make a brief summary of this post so that other forum members could easily find useful information here:
Issue Symptom:
First run Exchange 2019 - ECP with error 500
Solution:
C:\Windows\system32\lodctr.exe /R
And then:
iisreset /stop iisreset /start
Also made reset of VD - ECP and OWA.
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