To make a new configuration that is similar to Release, I think that you should also add these lines:
<PropertyGroup Condition="'$(Configuration)|$(Platform)'=='MyConfRel|AnyCPU'">
<Optimize>True</Optimize>
</PropertyGroup>
Actually, you can use the Visual, Studio, go to Project Properties and see the differences between configurations, but you should select the "Vary value by Configurations" option that appears for menues.