Yes you can.
Blazor WebAssembly can be deployed as static files without the need for server-side rendering.
We can publish the Blazor applications as like static files without the requirement of a web server or its interactions, since WebAssembly is a technology that executes entirely in the client browser. Although we can do advanced logic in client side using C# in the browser, however, to interact with data, database or other services, this type uses standard web technologies HTTP services.
And to communicate with backend or Database we use Web API. Therefore, we will have separate solution/project for Web API where you can use entity framework or any ORM.
For more details:
[https://rijsat.com/2022/11/07/what-is-blazor-web-development/