@EnterpriseArchitect, Thanks for posting in Q&A. The "Enforce script signature check" setting in the Intune Portal is used to determine whether a PowerShell script must be signed by a trusted publisher before it can be executed on a device. When the "Enforce script signature check" setting is enabled, scripts need to be signed, and the certificate is added to the Trusted Publishers certificate store of the device. If you are using third-party scripts that are signed, make sure the certificate is in the Trusted Publishers certificate store. As with any certificate, the certificate authority must be trusted by the device.
Hope the above information can help.
If the answer is helpful, please click "Accept Answer" and kindly upvote it. If you have extra questions about this answer, please click "Comment".
Note: Please follow the steps in our documentation to enable e-mail notifications if you want to receive the related email notification for this thread.