Thank you for posting your query on Microsoft Q&A, from above description I could understand that you are wanting to exclude the URL from Microsoft Office defender safe links policy so that trend micro could be used to take allow/block action by accessing the links in email.
Please do correct me for any discrepancies in my understanding by responding in comments.
Just excluding may not help here as
Entries in the "Do not rewrite the following URLs" list aren't scanned or wrapped by Safe Links during mail flow, but might still be blocked at time of click. Report the URL as Should not have been blocked (False positive) and select Alow this URL to add an allow entry to the Tenant Allow/Block List so the URL isn't scanned or wrapped by Safe Links during mail flow and at time of click.
Kindly try following the given steps:
- Exclude the URL from the policy by adding URL to "Manage URLs to not rewrite". : Entries in the "Don't rewrite the following URLs" list aren't scanned or wrapped by Safe Links during mail flow.
- Also, report the URL as Should not have been blocked (False positive) and select Allow this URL to add an allow entry to the Tenant Allow/Block List so the URL isn't scanned or wrapped by Safe Links during mail flow and at time of click.
For instructions, see Report good URLs to Microsoft.
---Please "Accept the answer (Yes)" and "share your feedback ". This will help us and others in the community as well.
Thanks, Akshay Kaushik