@Van M , Thanks for posting in Q&A. From your description, I know there's no GPO set to block USB access. If the device is managed by Microsoft Intune, please also check if any policy applied to the device which block the USB access. You can go to Intune portal, Devices, find the affected device, click Device Configuration to verify the policy applied to the device.
If there's any update, feel free to let us know.
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