Hi John,
Thank you for reaching out to us on the Microsoft Q&A forum.
As an original poster cannot accept their own answer, I am reposting it so that you can accept it an answer. Accepted answer will help other community members navigate to the appropriate solutions.
Issue: Does Front Door origins support wildcard hosts?
Solution: Setting a dummy subdomain in the origin host forwards the original host in the request to the origin. What I wanted was to set the origin host name to something like *.example.com, which is not possible, but x.example.com (or any string before .example) works. I also set the origin host header to blank.