Using Classic Outlook on Windows for personal email, calendar, and contact management
Hello SMMT_CENTER,
Thank you for posting to Microsoft Community.
I understand that you have an issue sending email with error code 451-'4.7.500. My apologies for the inconvenience that this is causing you.
From the error code, this error usually happens due to IP throttling or when the source IP address that's sending you email changes significantly from its previously-established patterns.
I therefore believe that this issue should be further investigated by our online technical support team. A support Engineer can further connect with you remotely, for further troubleshooting and involve the backend team where need be. The team might request for your public IP address or collect some logs from your outlook.
Please understand that as public forum support, we don’t have higher permissions to check and analyze these logs or check the IP addresses and considering your scenario maybe inconveniencing, to quickly help assist, kindly contact your organization admin or you can create a service request to report this symptom to our online channel through the O365 or Teams admin center through the Help & Support button on the bottom right of the page. Please write the error code 451 4.7.500 in the request ticket.
Ref: Get support - Microsoft 365 admin | Microsoft Learn
Your patience and cooperation are much appreciated.
Thanks again for your time and have a great day.
Best Regards,
Ashraf