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hi callum,
thanks for your update.
as you said, you can't run admin as it is greyed out. therefore, you should not be a local administrator. based on my research, we need the local administrator right to use it. refer to this article: https://ashley.geek.nz/2013/10/24/sharepoint-2013-workflows/ . so please make sure you are the local admin first to check the outcome.
in addition, based on our initial troubleshooting, the issue should not be related to online services which are supported in this forum. therefore, we suggest you turn to sharepoint designer forum for depth assistance.
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your understanding is highly appreciated.
sky