Hi @Jerry Kots,
Thank you for posting your question in the Microsoft Q&A forum.
To remove duplicate when comparing two data columns, you can try using these workarounds:
1- Conditional Formatting
You can use Conditional Formatting in Excel to highlight the duplicate cells and delete them manually.
- In my test sheet, I created two data columns like this. To find duplicate value between two columns, I will select column B > in Home tab > Conditional Formatting > New rule

- Add the formula to compare cell =COUNTIF(A:A, $B1)>0 and format it to be colored in red

- After pressing OK, the duplicates will be colored, and I can delete them manually.
2- Using helper columns
This is the same approach as conditional formatting, but this option will use formula in a help column to identify rows containing duplicates.
- In a helper column (in my test sheet I use column D), use this formula =IF(COUNTIF(A:A,B1)>0, "Duplicate","") in cell D1 and drag down the formula
- It will show results on rows that containing duplicate cells of column B.

3- Use Excel built-in remove duplicates
- Copy both columns into a single column
- Select the new combined one and go to Data > Remove Duplicates

If you're having large data sheet, there is an option for using PowerQuery. However, for further assistance, can you share us the sample data so we can take a look and understand the situation clearly to provide the most appropriate solution for your request.
Please understand that our initial response does not always resolve the issue immediately. However, with your help and more detailed information, we can work together to find a solution.
Thank you for your understanding and cooperation. I'm looking forward to your reply.
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