Hi Corne Hendrickx,
Thank you for reaching out to Microsoft Q&A
In your APIM Instance > Can you visit > Diagnose & solve problems > Availability & Performance > And see if you can get an insight on why the API response is slow.
APIM’s SSL Hello timing is primarily influenced by the client’s path to your gateway hostname and the certificate chain it receives. Backend API slowness shows after the handshake, and APIM guidance recommends Inspector traces to confirm where time is spent. https://learn.microsoft.com/en-us/troubleshoot/azure/api-mgmt/availability/performance-hit-api-calls