issue is resolved..
Turns out it was the front end optimization on the netscaler that caused it. NS were updated in July with new firmware and perhaps it has more aggressive optimization or new browsers have code that do not play well with it. Client had fe optimization enabled before so both combination of new firmware and browser updates likely contributed.
It make more sense now why mobile site and owa light mode worked all this time as traffic sent between client browser and server is significantly less compared to normal mode so not much http traffic to optimize anyway
we didn’t have to test with single server in the lb pool, that was next in line🙂
All browsers now work, no issue
Thanks for all your suggestions
NS